In recent years, weight-loss medications have taken the healthcare industry by storm. No longer just a niche treatment for obesity, these drugs—especially GLP-1 receptor agonists—are now at the forefront of a pharmaceutical revolution. But how transformative are they really?
WORDS LIM TECK CHOON
 FEATURED EXPERTKEVIN BEN LAURENCE Director FIP Foundation for Education and Research |
Kevin Ben Laurence is a seasoned pharmacist and Director at the FIP (International Pharmaceutical Federation) Foundation for Education and Research.
As the first and only pharmacist licensed in Singapore, Indonesia and Malaysia, Mr Laurence shares how weight-loss medications are reshaping the pharmaceutical landscape, their benefits, risks, and the future they herald for healthcare.
A GAME-CHANGER, BUT NOT A MAGIC BULLET
Weight-loss medications are often marketed as life-changing, but Mr Laurence urges caution.
“GLP-1 receptor agonists have indeed revolutionized weight management, offering a scientific approach to addressing obesity,” he says.
“However, while they provide significant benefits, their effectiveness varies among individuals, and they are not a universal solution,” he adds.
The biggest takeaway is that these drugs are most effective when used as part of a holistic approach that includes lifestyle changes. They are a tool, not a cure-all.
BENEFICIAL FOR INDIVIDUALS WITH CERTAIN HEALTH CONDITIONS
Mr Laurence reveals that, for individuals with diabetes or hypertension, weight loss drugs can be beneficial in managing these conditions.
“They must be used under medical supervision,” he cautions.
He further explains that this is because certain medications may lower blood sugar levels significantly, increasing the risk of hypoglycaemia. Others may interact with blood pressure medications, necessitating dosage adjustments.
THE SIDE EFFECTS: WHAT YOU NEED TO KNOW
Effects on Physical Health
Like any medication, weight-loss drugs come with risks. The most common side effects include:
- Nausea
- Vomiting
- Diarrhoea
- Constipation
- Fatigue
More serious concerns have also surfaced.
- Some studies suggest a link between GLP-1 drugs and worsening diabetic retinopathy.
- He further explains: “This is thought to be due to rapid weight loss and its impact on blood vessels. While the absolute risk is low, individuals with preexisting eye conditions should have regular check-ups.”
- While such occurrences are rare, Mr Laurence recommends that individuals with preexisting eye conditions should have regular eye check-ups when they are on these medications.
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Effects on Mental Health
Some patients report mood swings, anxiety, or even depressive symptoms while on these medications.
“The direct link is not fully established,” says Laurence, “but significant changes in appetite and metabolism can influence mood. Patients should be monitored for psychological side effects.”
COSMETIC USE: A DANGEROUS TREND?
With weight-loss drugs becoming widely available, some people are using them not for medical necessity but for aesthetic reasons.
Mr Laurence warns against this. “These medications are designed for individuals with obesity or weight-related health conditions. Using them solely for cosmetic reasons can lead to nutrient deficiencies, muscle loss, and adverse metabolic effects.”
He stresses the importance of consulting healthcare professionals before starting any weight-loss medication. “Pharmacists are the drug experts—seek their advice before making a decision.”
ARE WE READY FOR THIS REVOLUTION?
Despite their increasing popularity, Kevin Ben Laurence believes that many healthcare professionals still need more training on these drugs.
“The growing demand has outpaced regulatory and educational efforts in some regions,” he notes.
So how can awareness be improved? Mr Laurence suggests:
- Continuous professional education (CPE) programs on the latest research and guidelines.
- Digital platforms like MIMS for widespread information dissemination.
- Better interdisciplinary collaboration among pharmacists, doctors, and endocrinologists.
- More patient education to ensure informed decision-making.
THE FUTURE OF WEIGHT-LOSS MEDICATIONS
The weight-loss drug market is expanding, and Mr Laurence anticipates several key developments in the coming years.
More Drugs, More Options
“The pipeline for weight-loss medications is growing, with new mechanisms of action being explored,” Mr Laurence tells us.
Stricter Regulations
Regulatory bodies will likely introduce stricter prescribing criteria to ensure appropriate use.
No Over the Counter (OTC) Variants (For Now)
“It is unlikely that GLP-1 agonists will become OTC due to their potential risks, but milder formulations may emerge,” Mr Laurence predicts.
A Shifting Healthcare Landscape
Mr Laurence muses that, with more effective weight management solutions, we may see reduced demand for obesity-related treatments like bariatric surgery, while nutrition and metabolic health services grow.
THE BOTTOM LINE
Weight-loss medications are changing the way we approach obesity and metabolic health. B
As with any powerful medical breakthrough, responsible use is key.
Kevin Ben Laurence offers this final piece of advice: “Weight-loss drugs represent an exciting advancement in healthcare, but their use must be approached with caution. Proper medical supervision and continuous education are essential to maximizing their benefits while minimizing risks.”
| Full Disclosure Kevin Ben Laurence is the Client and Society Partner of MIMS Medica, the publisher of HealthToday. However, this article was created independently and without commercial influence. |
| This article is part of our series on research-based weight loss methods and medical options. |
