The Anti-Cancer Factor

The Anti-Cancer Factor

April 29, 2022   Return

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Professor Dr Ammu K Radhakrishnan   Professor of Pathology (Immunology), International Medical University

“My friends always tell me, ‘Oh, there you go again, about tocotrienols!’ They feel that I am always talking about tocotrienols,” says Prof Dr Ammu K Radhakrishnan with a laugh. “But even if I talk a lot about them, many people are still unaware of their benefits!”

Prof Ammu is one of the many researchers who are studying the potential benefits of tocotrienols, a group of vitamin E compounds, in the fight against cancer. In Malaysia, there is significant research activity, because one of the richest sources of tocotrienols is palm oil. Establishing the benefits of tocotrienols would not only boost our health, but our country’s economy as well!

The wolf in sheep clothing

Back to the topic of cancer, have you ever wondered why our immune system does not stop cancer cells from growing, the way it stops germs and viruses?

Prof Ammu explains that the immune system fails to recognize the threat because the cancer cells are actually our own cells turned “rogue” i.e. these cells express many of the same chemical structures on their surface as their normal counterparts. “As far as our immune system is concerned, the cancer cells are the same as our normal cells. In fact, there is a possibility that a subset of T-lymphocytes known as the T-regulatory cells will prevent activation of our immune system against the cancer cells, thereby inhibiting our natural anti-cancer effects.” 

Therefore, cancer cells are not just wolves in sheep’s clothing – the sheep are protecting the wolves!

Anti-cancer properties

So, how are tocotrienols useful against cancer? Research offers some interesting clues.

Inhibits growth and spread of cancer cells.

Prof Ammu was involved in a research which found that tocotrienol supplementation can inhibit tumour growth and spread. Additionally, it enhances the tumour-killing activities of the immune system (specifically, that of cytotoxic T-lymphocytes).1  

Promotes death of cancer cells.

Prof Ammu was also involved in another study, which showed that tocotrienols can induce cell death in breast cancer cells. They activate the gene responsible for the production of an enzyme known as poly(ADP-ribose) polymerase (PARP), which is involved in cell death. They also inhibit the production of certain substances (nuclear factor kappa-B or NF-ƙB) that trigger cell proliferation and inflammation.  As a result, cancer cells become more sensitive to factors that can activate their cell death.2

“Additionally, there are studies which suggested that tocotrienols can help inhibit the growth of blood vessels necessary for cancer cells to proliferate,” adds Prof Ammu.

Furthermore, there are suggestions that tocotrienols affect cancer cells without affecting normal cells as well, and they may even exert protective benefits against radiation.

“Therefore, it is possible that there could be great synergy between tocotrienols and cancer treatments,” says Prof Ammu. 

References:

Abdul Hafid, S.R., et al. (2013). Tocotrienol-adjuvanted dendritic cells inhibit tumor growth and metastasis: a murine model of breast cancer. PLoS One; 8(9): e74753. doi: 10.1371/journal.pone.0074753. eCollection 2013.

Loganathan, R., et al. (2013). Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity. Cell Prolif; 46(2): 203-13. doi: 10.1111/cpr.12014.

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I mQUITting… How about You?

I mQUITting... How about You?

April 29, 2022   Return

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E_Dr Amer

Assoc Prof Dr Amer Siddiq Amer Nordin   Consultant Psychiatrist, University of Malaya

“Smoking cessation is something every doctor should know,” Assoc Prof Dr Amer Siddiq says as he sits down to share with HealthToday a little bit more about mQuit, a smoking cessation programme recently launched by the Ministry of Health in co-operation with University of Malaya, Universiti Sains Malaysia, Akademi Farmasi Malaysia, and Johnson and Johnson Sdn Bhd.

He sees parallels between his journey from medical student to smoking cessation specialist and the current mQuit programme. “My mentor was Professor Dr Mohamad Hussain Habil, who encouraged me to pursue my PhD in smoking cessation, and he felt that there was a need for more medical professionals to be better equipped to handle this matter,” he says. The Professor was the past Director of the University of Malaya Centre for Addiction Sciences, of which Dr Amer is currently the Chief Coordinator, and theirs is a relationship that thrives to this very day. “And it was during the course of that journey that I realized how many of my colleagues in health – doctors, dentists, nurses, pharmacists – were ill-equipped to help their patients stop smoking.” With that realization, came the epiphany that it was his calling to help train and assist his fellow medical colleagues in empowering their patients to quit the habit.

Hence, Dr Amer was one of the many experts called on to assist in making mQuit a reality. The University of Malaya, of which he is affiliated to, has contributed a curriculum called Smoking Cessation Organizing, Planning and Execution (SCOPE), which is one of the three training programmes used by mQuit to assist healthcare providers to have adequate training and competence to help patients quit smoking.

What is mQuit?

The mQuit programme is the first wide-scale programme of its kind, as it brings together both the public and private healthcare sector to devise an integrated quit-smoking plan.

Dr Amer says that the mQuit programme draws inspirations from successful programmes in other countries, such as the Stop Smoking Service by UK’s National Health Service.

“It’s a revolutionary change,” Dr Amer opines. “It provides impetus to our smoking cessation efforts by upgrading existing facilities and introducing new ideas and strategies.”

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What mQuit Offers

You and your loved ones

  • A network of mQuit Centres that you can attend to quit the addiction.
  • The Centres will devise a healthcare professional-customized plan using the latest treatment methods (nicotine replacement therapy, medicines and behavioural therapy) and introduce smoking cessation aids that are five times more effective than using willpower alone.
  • Follow-up sessions, support, and advice to help beat cravings.
  • Establishment of a national quit line (coming soon).
  • Online hub www.jomquit.com.my to provide cessation support and drive smokers to mQuit centres. Currently the website is in English, with the Bahasa Malaysia version coming soon.

Medical professionals

  • Training programmes to upgrade knowledge and ability to help patients quit smoking. Trained personnel can apply for accreditation that qualifies their medical establishment to be identified as an “mQuit Centre”. Official mQuit plaques would be provided.
  • Provides a private-public partnership that facilitates more active participation of private clinics and hospitals in government-run smoking cessation campaigns and programmes.
  • Develops and provides a set of clinical guidelines that will be continuously updated. Dr Amer says that the guidelines are already in the final stage of development, to be released later this year.

How effective will mQuit be?

The mQuit smoking cessation programme revolves around evidence-based treatments that have been scientifically proven to be effective. It will also encourage more treatment options to be introduced into Malaysia, which will benefit Malaysian smokers as a whole.

Currently, the key challenge is to equip the relevant healthcare professionals in this country – family medical specialists, general practitioners, dentists, pharmacists, nurses, etc – with the knowledge and tools to devise effective stop smoking strategies for their patients. This can be a daunting task, but the mQuit team is up for the challenge.

Much effort is being spent on promoting awareness of the programme. Dr Amer explains that the experts involved, such as himself, contribute to the cause by shining the spotlight on mQuit during local conferences such as the recent Malaysian Congress for Psychological Medicine.

He further elaborates that his group has been working closely with other partners in the healthcare arena. They have trained over 1,600 healthcare providers so far, and these healthcare providers are, in turn, drumming awareness into their own colleagues.

“This is a nationwide programme,” he adds, “and already we have conducted four trainings in Sarawak and another two in Sabah. In the Peninsula, training would move from the central region to the North and East Coast later this year.”

He reiterates that mQuit is a long-term programme. It has set some goals for itself:

  • Reduce the prevalence of smoking by 15% by 2025.
  • Reduce this prevalence to less than 5% by 2045.

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So, is today the day to change your life?

  • If you are a smoker who wish to quit, visit www.jomquit.com.my to be inspired and to locate the nearest mQuit centre, to begin the journey to a smoke-free new you.
  • If you are a healthcare professional that have recently undergone smoking cessation training under the SCOPE/CSCSP/KKM/overseas certified programme, the Ministry of Health currently allows for fast-track application for accreditation of the mQuit services.

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Vaccines under Fire

Vaccines under Fire

April 28, 2022   Return

NE_Datuk Dr Zulkifli...

Datuk Dr Zulkifli Ismail   Consultant Paediatrician & Paediatric Cardiologist

One of Datuk Dr Zulkifli’s closest childhood friends, Johanuddin, contracted polio when he was a child. He was not vaccinated against the wasting disease. Dr Zul, as he is popularly known as, recalls how, when they were children, he would help carry Johanuddin’s school bag for him. Johanuddin spent his early adult days using calipers on his legs, then needing a walking stick and later a crutch, before eventually having to use a wheelchair. As a close friend of that man, Dr Zul knows firsthand how a single vaccination could have prevented a disease that would affect a person for the rest of that person’s life.

Thus, it is not surprising that, in addition to being a paediatrician, Dr Zul is also well-known as a passionate advocate for vaccination as one of the most important means of prevention of selected infectious diseases. Earlier this year, he was involved in the writing and publication of the book Immunisation Controversies: What You Really Need to Know, which addresses common misperceptions harboured by many Malaysians with regard to vaccines. He is also an active key figure in the Malaysian Paediatric Association as well as parenting educational programme Positive Parenting (www.mypositiveparenting.org) and the vaccination education and awareness programme Immunise-4-Life (www.ifl.my).

With his credentials, we at HealthToday can’t think of a more suitable person to put on the hot seat.

#1: USD3.18 billion awarded to people harmed by vaccine.

The US Government established the National Vaccine Injury Compensation Programme (VICP) in 1988. Since that year, the Vaccine Compensation Court has awarded more than 16,000 families claiming to have been harmed by vaccines, for a total award of USD3.18 billion! Isn’t this evidence that vaccines can be harmful?

Dr Zul:

The number may seem frightening, but we need to take a look at the whole picture.

According to the US Health Resources and Service Administration website (which is run by the US government), over 2.5 billion doses of covered vaccines were distributed in that country from 2006 to 2014. There were 3,491 petitions handled by the Court, and 2,224 of these received compensation. This means that about 1 individual is compensated for every 1.2 million doses of vaccine distributed.

If you look at the number, it’s actually small. In fact, this figure is to be expected, as it corresponds to the risk of vaccine adverse events. For example, only one case of severe allergic reaction is reported for every 1 million doses of measles, mumps and rubella (MMR) vaccine distributed.

Therefore, when you see such numbers, there is nothing to be alarmed of. The risk of developing serious side effects is very small, and the doctor will ask you about your health status before administering a shot, in order to minimize this risk.

#2: Hannah Poling’s autism was caused by her vaccines.

We hear a lot about how the so-called research by Dr Andrew Wakefield, which linked vaccines to the development of autism in children, is thoroughly discredited. And yet, in 2008, the VICP awarded Hannah Poling over USD1.5 million when they determined that her autism developed after receiving five vaccines: diphtheria–tetanus–acellular pertussis, Haemophilus influenzae type b (Hib), MMR, varicella, and polio. So, Dr Wakefield is right, after all!

Dr Zul:

Pinpointing the cause of autism is not easy. We do not know, to this day, what the exact causes are, only that it is very possible that several factors can act in combination to give rise to the condition. We cannot simplify things by pinpointing to vaccines alone as the cause of autism.

With regard to Hannah Poling, this is not as clear cut a case as it seemed on paper. Hannah had several medical conditions from young (including frequent episodes of fever and otitis media), and it is possible that her autism may be caused by a combination of factors that may or may not include receiving her vaccines.

As for Dr Wakefield, he was exposed by a journalist, Brian Deer from the UK Sunday Times who had nothing to do with the medical industry (so no bias or self-interest there!), and he was found to have his own personal interests in seeing vaccines discredited. The research methodology used by him was deeply flawed, irreproducible, even fraudulent, and the paper was thoroughly discredited. So, there is no question as to whether he is right – he isn’t, and he is even barred from practicing in the UK, his own country. 

There are many research papers, published in respectable journals, which have demonstrated that vaccines do not cause autism. The autism claims are all based on a single paper that has been thoroughly discredited over the years. Which would you rather believe?

#3: Vaccines get recalled for safety reasons.

There are well-documented cases of vaccines being called back or withdrawn from the market due to reports of serious side effects. A rotavirus vaccine, for example, had been recalled after it was linked to intussusception, a rare bowel obstruction condition, among babies. Does this mean that members of the public are ‘guinea pigs’ for these pharmaceutical companies to test their products?

Dr Zul:

Let me start by saying that the way vaccines work has come a long way from what we were taught in school. These days, we have developed conjugate vaccines that stimulate the T-memory cells in our body. This improves the body’s future immune response against the specific infection. Therefore, the vaccines today are better, more efficacious and safer.

On the matter of recalls, again, we need to look at the big picture. The numbers of recalls are very small compared to the number of vaccines being distributed. This is because vaccines are continuously monitored by the manufacturer as well as doctors and other relevant authorities, both before and after the vaccines are in use, and often, recalls are made immediately after a cause for concern is discovered.

The rotavirus vaccine that you mentioned was taken off the market after it was found that it was directly related to intussusception in the babies who had received it. This actually proves that the authorities can force industry to stop distribution and production of any vaccine when there is evidence of severe adverse events.

Also, in Malaysia we usually receive vaccines some time (possibly several years) after they were in use in America or Europe, due to the stringent approval process by our Ministry of Health and other factors. By the time a vaccine is approved, its safety and side effects are already well documented. It goes without saying that only the safe-to-use ones will be approved in this country!

#4:Vaccines are not halal?

Muslims should not be expected to accept non-halal vaccines. It is not right!

Dr Zul:

To Muslims concerned about the halal issue, there is some good news: work is done to produce halal vaccines. While we don’t have release dates for such vaccines, we are getting there!

Meanwhile, the current vaccines may not bear the halal stamp, but Islamic bodies both in Malaysia and the rest of the world have stated that it is fine to use these vaccines.

As a Muslim, I am personally concerned about this matter, for myself, my family and my Muslim patients. I went and found out myself how these vaccines are made. While some vaccines may have ingredients taken from pigs, the end vaccine product contains no pig genetic material due to the manufacturing process that includes dilution and refining.  Polymerase chain reaction (PCR) tests on vaccines that use porcine material in their manufacture has revealed no pig DNA in them. This should allay any fears among Muslims in addition to the opinion of scholars.

Furthermore, the Quran states that it is the partaking, or eating, of pork that is forbidden. It does not prohibit the breaking down of porcine elements into molecules to produce a vaccine that will be injected into our body. 

#5: Vaccines are optional, not compulsory

Despite claims that it is our responsibility to vaccinate ourselves and our children, the government has not made it compulsory for us to do so. Is the importance of vaccines, therefore, overstated?

Dr Zul:

Making something compulsory is not as simple as just making and passing a law. I am not a politician, so I can only speculate, based on what is happening in the US, where some states require that certain vaccines must be given to children before they can enroll into school.

Some things to consider – do we want to deny children the right to education just because their parents did not arrange for them to be vaccinated? Would such a law only drive the anti-vaxxers more ‘underground’? There is also a need to create a body to address claims filed by people who feel that they have been harmed by vaccines, such as VICP in the US, as well as a compensation policy.

As you can see, making vaccinations compulsory is not so simple. Its implementation can have effects on other aspects of our lives, so everything has to be considered carefully. Therefore, whether or not vaccination is made compulsory does not change the fact that it is still an important preventive measure against potentially deadly infections.  There is no need to fear vaccination. After all, vaccines sitting on shelves don’t save lives, vaccination does!

References:

The New England Journal of Medicine. Available at www.nejm.org.

US Centers for Disease Control and Prevention. Available at www.cdc.gov.

US Health Resources and Service Administration. Available at www.hrsa.gov. 

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The Brain Matters

The Brain Matters

April 28, 2022   Return

Nothing can be more heart-aching than having to witness a loved one gradually lose themselves, forgetting things they supposedly know by heart and not being able to recall happy memories you both share. You dread the day when they forget your name, but that is often the case with people who have Alzheimer’s disease. After all, it is a disease which robs a person’s brain of its normal functioning. Even more terrifying is the likelihood that it could potentially happen to you in the future.

Award-winning journalist and bestselling author, Maria Shriver had her life touched by Alzheimer’s when her late father, Sargent Shriver, was diagnosed with the debilitating disease in 2003. Watching her father’s mind – which she described as “a finely tuned instrument that left people in awe and inspired” – slowly deteriorate until his death in 2011 prompted her to learn more about the condition. Ever since then, Shriver was a fervent advocate in raising public awareness and research funding for Alzheimer’s.

Her efforts have led to the production of a children’s book, What’s Happening to Grandpa?, the documentary series The Alzheimer’s Project, and the special report A Woman’s Nation Takes on Alzheimer’s. Shriver was also an executive producer of the highly-acclaimed movie Still Alice, in which actress Julian Moore plays a college professor who showed signs of early onset of Alzheimer’s. 

Shriver wants to send a clear message that Alzheimer’s is a disease, and not a natural part of aging. In her work, she emphasized that it is largely a “woman’s disease”, since women make up nearly two-thirds of those diagnosed in the US. Furthermore, more than 60% of unpaid caretakers to family members with Alzheimer’s are women who often ended up dropping out of the workforce to fulfil their roles.

While Alzheimer’s is a progressive brain disease with no cure, it may be prevented with healthy lifestyle choices, such as regular exercise, eating healthy and engaging in brain-stimulating activities. However, so many questions on the risk factors of Alzheimer’s in women are still unanswered. Hence, Shriver launched the Wipe Out Alzheimer’s Challenge campaign in 2015, to engage women as well as to promote education and empowerment on this disease.

Shriver went on to launch another initiative targeting women, called The Women’s Alzheimer’s Challenge, which held its first fundraiser and educational event in May 2016. The initiative is intended to fund gender-specific research on Alzheimer’s disease. As she noted in a 2015 CNN article, “Women are the epicentre of this crisis, which is why I believe they also have to be the solution”.     

References:

CNN. Available at www.edition.cnn.com

Huffington Post. Available at www.huffingtonpost.com

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Don’t Be Spineless!

Don’t Be Spineless!

April 28, 2022   Return

We often refer to the most important component of something as the ‘backbone’ – the key element that holds everything together. When the human body is concerned, the expression takes on a literal meaning, since the spinal column is the most crucial series of bones that holds the entire musculoskeletal structure in place. Yet, many of us tend to take our spinal health for granted.  

Understanding Our Anatomy

According to the World Health Organization (WHO), spinal and bone problems are one of the greatest threats to our well-being, right after cardiovascular disease, cancer and diabetes. Indeed, the spine does more than just enabling us to stand upright; there are nerves running down the spine that control many of the body’s sensory, metabolic and various other vital bodily functions.

The spine consists of 33 individual bones – known as the vertebrae – that are interlocked together. The entire spinal column is divided into four regions: the neck (cervical), mid-back (thoracic), lower back (lumbar) and tailbone (sacrum and coccyx). Only the first three regions made up of 24 vertebrae are movable, while the remaining nine pieces that form the tailbone are fused.

When a Backache is Not Just a Backache

Do you often have to place one hand on your waist and hold on to something for support when getting up from a seated position? The backache could be just be a minor sprain or caused by something in your gene code, but whatever the cause, it is definitely an indicator that your spine is crying out for help.

“There are many different types and severity of spinal condition, from mild musculoskeletal conditions such as sprains and strains to moderate conditions like ‘slipped discs’, or severe conditions such as cauda equina syndrome that requires immediate surgical intervention,” explains Dr Rita Wong,  a registered chiropractor.

She further clarifies that problems in the spine can either be congenital and acquired. “Some spinal conditions have a strong genetic predisposition, such as scoliosis (a side bending of the spine) and ankylosing spondylosis (a chronic inflammatory autoimmune spinal condition). However, acquired spinal problems often result from lifestyle habits or trauma-related injuries,” says Dr Wong.

With so many possibilities that could cause backache, here are some significant signs and symptoms that may signal serious spinal problems. According to Dr Wong, they should not be taken lightly and require prompt medical attention.

  • Pain that does not subside after a few days
  • Frequent numbness or tingling in the hands and feet
  • Significant muscle weakness or wasting
  • Loss of deep tendon reflexes
  • Onset of bowel or bladder dysfunction
  • Sensory loss in the buttock area
  • Pain that remains when lying down and causes sleep disturbances
  • Fevers and chills that are accompanied by unexplained weight loss

Additionally, Dr Wong cautions those with a medical history of cancer to pay extra attention to spinal pain. “Breast, lung, gastrointestinal, prostate, renal, and thyroid cancers are more likely to metastasize in the spine,” she said. The same also goes for those who had suffered major or minor trauma from physical injuries, as they are at risk of developing serious mobility problems in the spinal column.    

Apart from these various possibilities, Dr Wong reminds, “Aging is the most common causes of spinal pain.”

The Perils of Modern Conveniences

For generally healthy individuals, spinal problems can develop gradually over time, often the cumulative result of prolonged lifestyle habits that ultimately take their toll. “Modern lifestyle has created many hidden problems for our spine. Immobility from prolonged sitting on office chairs and sofas causes back stiffness and radiating buttock pain, known as sciatica. People spend long hours in front of computers and mobile devices with their head tilting forward and mid-back hunching,” said Dr Wong.

Unfortunately, early signs of spinal problems are usually ignored or dismissed as tiredness from overworking or harmless muscle strains. If you habitually work before a computer for hours on end, and exercise less than three hours per week, these signs may be a cue to start paying attention to your spinal health:

  • Bone cracking sounds can be heard when you move your neck, back or joints
  • Your neck and back have poor range of motion
  • You often feel tired or have difficulty concentrating
  • Your feet turned out when you walk
  • You tend to slouch when sitting or walking
  • You experience pain in the eyes, shoulder, neck and lumbar region

Move that Body!

Maintaining good spinal mobility and slowing down the effects of aging comes down to an obvious yet often overlooked fact: Our bodies are not meant to be sedentary. “Movement is the key to a healthy spine. I would recommend people to get up and walk around every 30 minutes at home or in the office. When driving long distances or taking long flights, be sure to move around every hour. Take a pit stop, or go to the washroom to promote spinal mobility throughout your drive. Some light stretches should also be done on our neck and back every morning and evening, before we start and finish work, in order to condition our muscles and ligaments for the daily activities we take part in,” Dr Wong  said.

While sports and workout-related injuries are among the common causes of spinal problems, the right kind of exercises is also the best prevention. According to Dr Wong, a strong core is the foundation to minimizing injuries.

“Core strengthening is more than just achieving six-pack abs. Developing strong core muscles may actually help prevent back pain by making you less susceptible to back injuries and maintaining proper posture. If you think about it, your core supports the spine, which is the axial skeleton of your body. It needs to be strong to assist in distributing the weight load of your entire body. By improving your core strength, you will also be less likely to rely on other back pain treatments and remedies. Core exercises should involve the major muscles in your abdomen, including your internal and external obliques and the transverse abdominals,” she advises. However, staying active is only half the equation. 

Nourishment for Your Spine

“A healthy spine includes maintaining the well-being of body structures such as bones, muscles and spinal discs,” says Dr Wong. This means ensuring one maintains a balanced diet rich in the essential vitamins and minerals.

Since the spine is basically bones, sufficient calcium intake is important to maintain bone density and prevent osteoporosis. While it does protect from brittle bones that may happen with aging, Dr Wong would like to debunk a common myth about the role of the go-to mineral for bone health, “Calcium does not prevent degenerative joint disease (osteoarthritis). It only supplies mineral to promote stronger bones. Degenerative joint problems usually result from the wear-and-tear of the joint, which is part of the aging process. After repetitive stress, the joint space became narrowed, but taking calcium would not increase the joint space, or reduce the degenerative process.

Luckily, calcium-rich foods sources also contain plenty other nutrients that promote overall spinal column health. Dairy products, dark leafy vegetables, tofu, nuts, lentils and beans are not only rich in calcium, but also iron, magnesium, and Vitamins, A, B12, D and K.

“Iron also aids in the production of myoglobin, an important element of healthy muscles that are needed to support the spine. Magnesium aids in the relaxation and contraction of muscles. It also helps maintain muscle tone and bone density, which in turn can help prevent back problems. Vitamin A is an antioxidant that assists the immune system in fighting off diseases, and helps with tissue repair. Vitamin B12 is beneficial to the bone marrow. Vitamin D helps to improve calcium absorption, which is important for the development of strong and healthy bones to prevent osteoporosis. Finally, the combination of vitamin K and calcium works to maintain strong and healthy bones,” Dr Wong elaborates.

She adds that fruits high in Vitamin C, such as citruses, kiwis, strawberries and tomatoes should also be the staple of one’s diet. “Vitamin C contributes towards the development of collagen tor healing injured tendons, ligaments and vertebral discs, as well as for keeping bones and other tissues strong,” concludes Dr Wong.

References:

Mayfield Clinic. Available at www.mayfieldclinic.com

Ge, T. (2015, Fall). Health Bones Part 1: Healthy Spine, Healthy Body. Meditation & Health; 5(2): 12

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Dengue & You: In Dengue’s Shadow

Dengue & You: In Dengue’s Shadow

April 29, 2022   Return

E_Dr Musa Nordin

Dato’ Dr Musa Mohd Nordin   Consultant Paediatrician & Neonatologist, Clinical Professor of Paediatrics

According to Dato’ Dr Musa Mohd Nordin, historical reports suggest that dengue fever was first reported in Peninsular Malaya in 1902. However, it was in 1962 when a colleague of Dr Musa, the late Datuk Dr N Paramaesvaran encountered and later reported the first few cases of dengue haemorrhagic fever (DHF) in children in Malaysia.

Dr Param was a registrar in the children’s ward at Penang General Hospital during that year. Children began coming in with high fever, red or purple spots on the skin caused by bleeding (petechiae), bruising, and nose bleeds (epistaxis). Further examination on those children showed signs including a palpable liver, bruising due to a low blood platelet count (thrombocytopaenia) and low blood pressure (hypotension).

A recent circular by the Institute for Medical Research, Malaysia (IMR) alerted the hospital to a recent DHF outbreak in Thailand, and Penang was at risk of facing its own outbreak due to its proximity to that country.

Paired blood sera samples from suspected dengue victims were sent for a diagnosis, and the late Dr Albert Rudnick, an American virologist, confirmed everyone’s worst fears: Malaysia was experiencing its first dengue epidemic right in Penang.

From epidemic to endemic

“There were no clinical guidelines then,” wrote Dr Param, “so we really struggled to manage those cases.”

Dr Rudnick had just returned from Bangkok after managing a DHF epidemic (Dr Rudnick, in fact, coined the phrase “dengue haemorrhagic fever”) and he wasted no time flying down to Penang to look into the possible outbreak.

The findings were presented at the World Health Organization (WHO) Meeting on DHF in 1964. After the meeting, Dr Rudnick killed an Aedes aegypti mosquito while they were at the Bangkok airport, and said, “This is how dengue arrived in Penang.”

Since then, much research has been done to improve our understanding of the underlying mechanisms of dengue and its complications. Despite this, the dengue problem continues to exist, and in fact, has escalated in Malaysia as well as in other parts of the world. Dengue is now endemic in over 100 countries, with 70% of cases concentrated in the Asia-Pacific region!

  • The first outbreak involved 41 confirmed cases and four deaths, but it was likely that many cases went unreported.

[1] Nordin M.M., & Paramaesvaran N. (2015, May 20). Dengue: then and now. Retrieved on September 15, 2015 from http://mpaweb.org.my/article.php?aid=807

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Dengue & You: It’s Time to Take Action!

Dengue & You: It’s Time to Take Action!

April 28, 2022   Return

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Professor Datin Dr Chia Yook Chin   Professor and Senior Consultant, Department of Primary Care Medicine, Faculty of Medicine, University of Malaya

Sarah Lian, TV personality and actress, is one of those adults who experienced firsthand the misery and pain caused by dengue. Like most Malaysians, she knows about dengue, but she never seriously gave it a thought until she had dengue in 2014.

“I was not sure how I contracted the disease,” she recalls, “but there was a construction site near my apartment – that could have been the cause.”

Fortunately, she recovered, thanks to early treatment as well as partaking in papaya leaf juice, a popular traditional remedy. Papaya leaf juice is clearly a drink that she is not too fond of, judging from her expression as she mentions it!

However, the uncertainties and misery she experienced while receiving treatment jolted her from the apathy she originally felt when it came to dengue. Today, she is an active advocate for dengue awareness, and she encourages Malaysians to take a more active role in eliminating the threat of dengue in our lives.

“I am proof that dengue can affect anyone and everyone,” she says, and reiterates the importance of each and every of us doing our part to eradicate the threat.

Uncertainties and Misery

“Patients with dengue go through quite a large amount of uncertainty, discomfort and fear ” says Professor Datin Dr Chia Yook Chin.

According to her, we currently do not have any specific medications for dengue. Antibiotics do not work on patients with dengue; treatment currently involves supportive care for the patients. Such supportive care includes:

  • Painkillers or analgesics for pain.
  • Fluid replacement (orally in mild cases, intravenous drips in severe cases).
  • Medications to lower fever.
  • In severe cases, blood transfusion and other bleeding management methods may be necessary.[1]

As you can see, patients with dengue can undergo considerable amount of uncertainty discomfort  and misery, and they may even face the possibility of death in particularly severe cases.

Additionally, there is the fear and worry that the patient and their family go through, beginning from the diagnosis process. “The wait for a diagnosis can be agonizing,” says Dr Chia. The affected patient has to come daily for blood tests, and sometimes it may take a while for the results to come in. There is also always the fear that the patient’s other family members would be affected by the disease.

When it comes to dengue, prevention is certainly a much more favourable and dependable option than cure. Let us take a look at how we can all do our part to protect ourselves from this disease.

First steps, first

  • Cover the gully trap of your sinks or install an anti-mosquito valve in each one.
  • Remove the tray of your air-conditioner. Hire a contractor to redirect the water from the air conditioner to the bathroom.

Every day, to keeps the mozzies away

  • Turn over or cover containers, bowls, plates and other utensils that can collect water.
  • Throw away all unwanted containers that can collect water.
  • Always cover your dustbin.

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Every 2 days, for better protection

  • For flower pot plates, discard collected water every two days and scrub the plate thoroughly to remove mosquito eggs. (It’s best not to use these plates in the first place!)
  • Change the water in flower vases. Flush the roots of the plant with running water, and scrub the inside of the vase thoroughly to remove mosquito eggs.

Once a week (that is what weekends are for!)

  • Clear drains of fallen leaves and other forms of blockage.
  • If you keep a garden, clear debris and remove any stagnant water collected on leaves and branches.

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Every month, for maximum protection

  • Clear roof gutters of blockages, and add some bleach solution or Bti insecticide. You can also use insecticidal paint on your roof gutters. 
  • In areas where the collection of stagnant water is unavoidable (such as at the playground near your house), add in some Bti insecticide or bleach solution.

If your area has plenty of mosquitoes

  • Wear long-sleeved shirts and long pants or skirts.
  • Place mosquito screens on doors and windows.
  • Use a mosquito net when you go to sleep.
  • Watch out for signs and symptoms of dengue.

[1] Medscape. Dengue treatment and management. Retrieved on Sept 17, 2015 from http://emedicine.medscape.com/article/215840-treatment

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Keep Dengue Away from Your Loved Ones

Keep Dengue Away from Your Loved Ones

April 28, 2022   Return

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The Aedes aegypti mosquito lays its eggs in clear, fresh water. Any area of standing water is a potential breeding ground.

Just 10 minutes!

Every weekend, spend 10 minutes checking your house for potential mosquito breeding spots and eliminating them. Use our checklist below as a guide. This is a small step, but you’d be amazed at how much difference it can make for you and your loved ones!

Getting started

  • Cover the gully trap of your sinks or install an anti-mosquito valve in each one.
  • If you use an air-conditioner, remove the tray. Hire a contractor to redirect the water from the air conditioner to the bathroom.

Do these every day

  • Turn over containers, bowls, plates and other utensils that can collect water and keep them dry. If you cannot turn them over, cover them.
  • Discard all unwanted containers that can collect water.
  • Ensure your dustbins are always properly covered.

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Do these every two days

  • If you use flower pot plates, discard collected water every two days and scrub the plate thoroughly to remove mosquito eggs. (It’s best not to use these plates in the first place!)
  • Change the water in flower vases. Flush the roots of the plant with running water, and scrub the inside of the vase thoroughly to remove mosquito eggs.

Do these once a week

  • Clear drains of fallen leaves and other forms of blockage.
  • If you keep a garden, clear debris and remove any stagnant water collected on leaves and branches.

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Do these once a month

  • Check roof gutters for blockages and clear any that is found. Add some bleach solution or Bti insecticide for added protection. Alternatively, use insecticidal paint on your roof gutters. 
  • In areas where the collection of stagnant water is unavoidable, add some Bti insecticide or bleach solution.

If your area has plenty of mosquitoes

  • Wear long-sleeved shirts and long pants or skirts.
  • Place mosquito screens on doors and windows.
  • Use a mosquito net when you go to sleep.
  • Watch out for signs and symptoms of dengue.

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The Unexpected Flu Car-rier

The Unexpected Flu Car-rier

April 28, 2022   Return

Anyone who has had the flu will agree just how awful it is. Nursing a sore throat, runny nose, fever and a pounding headache all at once is no laughing – or should I say, sneezing (pardon the pun) – matter. But jokes aside, influenza is one illness which must not be taken lightly.

While many recover from it in one to two weeks’ time, some people from high-risk groups like the elderly end up developing life-threatening complications including asthma and pneumonia. The United States’ Centers for Disease Control and Prevention reports that during influenza season, approximately 90% of flu-related deaths occur in those aged 65 and above. But the elderly aren’t the only ones affected; children are also high on the list. Statistics show that influenza causes more child hospitalizations than any other vaccine-preventable disease.

Doing our best… or are we?

Most of us are aware of the flu and just how harmful it can be, so much so that we try minimizing our risk of infection. Lathering on hand sanitizers to wearing facemasks to wiping down faucets, door knobs and other parts of our homes – we have done them all. Or have we, actually?

It is crucial to have our homes flu-proof but what about our cars? Just like homes, cars are also a great breeding ground for germs.  Think about it, we spend a considerable amount of time in our cars traveling from this place to that; we even eat and drink in there; unknowingly, we have had our hands all over its surfaces (door handles, radio buttons etc).

In light of this, we have come up with a list of tips to help you prevent your car from becoming a germ-teeming petri dish of sorts.

The wipe down.

Wiping down your car’s steering wheel, window switches, dashboard and seatbelts with sanitizing wipes is a must considering how frequently you and your passengers come in contact with these surfaces. But as tempting as it may be to wash harness straps in the washing machine, don’t. The force will ruin their fiber strength and fire retardant properties. Also, stay away from harsh chemicals like bleach as they might damage your vehicle’s interior. Mild soaps and damp cloths are fine, though.

Wipes aside, remember to stock up on tissues. Encourage your kids to sneeze or cough into tissues instead of into their bare hands or worse, right in someone else’s face.

Trash it.

There’s no better germ breeding ground than a car strewn with rubbish so always bin your trash. It can be as simple as using a makeshift plastic bag for a car litter bag and throwing it away (along with your food wrappers, used tissues and all) at the end of each day. If you are willing to splurge a bit, purchase a proper car litter bag. There are ones with spill-proof liners (no more spillages on your car upholstery) and cinch tops (goodbye, malodours!).

Sanitize!

Hand-washing is crucial for stopping the spread of germs but when you find yourself in the car with no running water and soap in sight, make do with some hand sanitizer instead. Whether it’s pumping petrol, snacking or sneezing, sanitizing your hands afterwards is important.

Get a shot!

Flu shots, to be exact. While keeping your car spick and span goes a long way, vaccination is your best insurance against the flu virus. In fact, a quadrivalent flu vaccine was recently developed to offer enhanced protection against influenza. So, don’t delay. See your doctor today and get yourself and your loved ones vaccinated!

References:

Car Pro. Available at www.carprousa.com

Centers for Disease Control and Prevention. Available at www.cdc.gov/flu

WebMD. Available at www.webmd.com

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Let’s Do Something Amazing: Why You Should Quit

Let’s Do Something Amazing: Why You Should Quit

April 28, 2022   Return

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Associate Professor Dr Amer Siddiq Amer Nordin   Consultant Psychiatrist and Smoking Cessation Specialist, UM Medical Centre, UM Specialist Centre & University Malaya Centre of Addiction Sciences

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Dr Rashidi Mohamed   Family Medicine Specialist, Hospital Canselor Tuanku Muhriz, UKM Medical Centre

Quitting smoking may not come easy to many smokers. Perhaps you are a smoker who have tried to quit many times but failed, or you may be a smoker who is thinking of quitting but is not sure of how to start? Or do you have a loved one who smokes, and you wish you can help him or her quit the habit?

Two experts on smoking cessation have come together to share information and tips to help you kick the habit. Yes, it can be done, and with some help from the right people and smoking cessation aids, it may be easier than you imagine. So, let’s do something amazing, let’s be amazing – let’s quit smoking for good!

Do you know what is inside a cigarette? Aside from the addictive nicotine, a cigarette contains about 7000 harmful ingredients that can be hazardous to your life, 69 of which are cancer-causing substances. Life is precious; you can only live once. So, if you smoke, quitting is the first step to living life to the fullest!

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Reason to quit #1: You will look good

Smoking can age an individual prematurely. It can also stain teeth and nails, and causes teeth and gum problems.  You will notice the difference, however, if you choose to quit. For better, of course; you will notice your skin clearing up, becoming brighter and more hydrated when you quit.

Reason to quit #2: You will smell good

When you quit smoking, you will no longer have the smell of stale tobacco hanging around you, even your sense of smell will improve. Any cough, wheezing and breathing problem caused by smoking will also show improvement 3-9 months after you quit smoking.

Reason to quit #3: You will have better health

When you smoke, you are exposing yourself to the risk of developing associated respiratory and cardiovascular diseases, diabetes and even cancer. Smoking still remains a leading public health problem and a major risk factor for the occurrences of these non-communicable diseases. But if you do happen to quit, your risk of developing such diseases will be reduced. Your heart health, blood circulation, sense of smell and taste will also improve; and your body will truly thank you for that.

Reason to quit #4: You can save for rainy days

Given the rising cost of living, you can certainly save a lot if you choose to quit. In fact, the money you spent to satisfy your smoke cravings can be put to good use. You can choose to spend it on groceries, household items, new clothing, sport equipment and even splurge on a decent holiday.

Reason to quit #5: Your loved ones will adore you

Your own health risk aside, you are also affecting other people’s health when you smoke in front of them. Think of your loved ones. You wouldn’t want them to suffer the same health consequences. Children whose parents are smokers are more likely to pick up the smoking habit later on. Quit smoking for the sake of your own health, your loved ones, your children and the surrounding non-smokers.

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Do you know?

  • The common age of smoking is between 25 and 44 years old.
  • The majority of current tobacco smokers are males (43.9%) with women smokers comprising about 1% or less. However, Dr Rashidi points out that the number of women who smoke is increasing.
  • Some people believe that smoking helps them to lose weight. Considering the other costs to health that come with smoking, is this the best way to shed the extra kilos? Experts certainly do not think so!
  • Others believe that smoking makes them more creative. However, frequent smoking can lead to addiction, and smokers could become more preoccupied with getting their next ‘fix’. This can actually hamper creativity!

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